Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
She emotes with some of Pink's husky attitude and some of Sia's theatrical so-over-it-ness, but she's a warmer singer than either, whether shrugging off a lover on the self-explanatory "IDGAF" or matching Miguel's intensity on the steamy "Lost in Your Light."
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Negative emotions such as worrying, stress, depression and anger visit type D personalities more often. A small event that is usually overlooked by others can bother a type D a lot and even ruin his mood.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Trends and targets in antiviral phototherapy
节目20 小品《今天的幸福2》，沈腾 马丽 杜晓宇 王琦
Concerns about China’s economy have recently dragged down global financial markets, affecting prospects for the eurozone and many others. Such worries are one reason why the European Central Bank is expected on Thursday to unleash a new round of economic stimulus.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
"We will set the exact date and location for our operation in consideration of weather conditions, but it will not be publicised," said Park Sang-Hak, a former defector who has led a series of balloon launches
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
China Hyundai dealers seek up to $135 million compensation
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
The first wearable computer glasses were made by Edward Thorp and Claude Shannon in 1961. In 1968, Ivan Sutherland made the "Sword of Damocles." It was the first head-mounted computer display and an early variant of all wearable computer glasses we have today. In 1980, Steve Mann, known today as the father of wearable computing, made the "WearComp", a pair of tech-enhanced glasses that was capable of communicating wirelessly with other computers and could share videos. He continued to work on the glasses over the years, and by 1999, he had come up with a pair of glasses that looked like Google Glass, or rather, that Google Glass looks like. He called it the "EyeTap."
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Among 36,000 who have reached celebrity status on the Internet, 74 percent are women and 87.8 percent are between 17 to 33 years old, while 89 percent have a college education.
In Belgium's case, the reasons are more readily apparent. A nation sewn largely from a patchwork of three peoples, the Flemish, Walloons, and Germans, its football team nevertheless features several stars of African descent. Currently, Belgians of Moroccan descent -- including midfielder Marouane Fellaini and winger Nacer Chadli -- make up the biggest non-European group; for many Moroccans, French is a second language. Like France with its North African and Caribbean contingents and Germany with its Turks, Belgium's national team has benefited from multiple populations: one from Western Europe, one from Africa, and one from Eastern Europe.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Issued by the Institute of Social Security Research, Ministry of Human Resources and Social Security, the report shows that the return rate of enterprise employees' pension insurance fund reached 3.1 percent, the highest in seven years.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
Many technicians think that during the course of this century computerized robots might compete and win against humans.
Leatrice Eiseman, the executive director of the Pantone Color Institute, said the joining of the two colors reflected “a soothing sense of order and peace” — presumably an attractive thing to incorporate into a product at a time of insecurity and global turbulence. It also implies that there is no line between “us” and “them.”
So, before the world gets the better of you and slaps a title on your forehead, create a unique manifesto of what you think you are.
Influenza neuraminidase: A druggable target for natural products
Mark Williams, chief Asia economist at Capital Economics, adds: “We expect that the performance of EM exports will continue to improve in 2017, with export values rising modestly in year-on-year terms.”
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
May happiness follow you wherever you go!愿您幸福快乐，直到永远永远。
After months have passed without a culprit in her daughter's murder case, Mildred Hayesmakes a bold move, painting three signs leading into her town with a controversial message directed at William Willoughby, the town's revered chief of police. When his second-in-command Officer Dixon, an immature mother's boy with a penchant for violence, gets involved, the battle between Mildred and Ebbing's law enforcement is only exacerbated.
The role of biosensors in the detection of emerging infectious diseases
东道主的对手阿根廷队在此次世界杯中也有很大的机会。一支以梅西为主的队伍都会在最后大放异彩，但是当你在队伍中增添类似塞尔吉奥·阿奎罗（Sergio Aguero）、冈萨罗·伊瓜因（Gonzalo Higuan）和埃泽奎尔·拉维奇（Ezequiel Lavezzi）这样的队员的话，那么它将是这届世界杯上最具有进攻打法的球队了。同理，乌拉圭的进攻三人组——路易斯·苏亚雷斯（Luis Suarez）、埃丁森·卡瓦尼（Edinson Cavani）以及迪亚戈·弗兰(Diegol Forlan)同样拥有同等的实力，能对世界上任何一支球队比赛时进球，不过，他们所在队伍中其他人的实力是否足够强还让人存疑。
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Less than an hour ago the official manufacturing PMI for November came in at 49.6, the fourth consecutive month of contraction and below the 49.8 reading economists were looking for. Analysts at ANZ said, in relation to that PMI series:“With soft growth momentum and deflation pressures creeping up, we expect the authorities to further ease monetary policy and continue to implement an expansionary fiscal policy in order to prevent further slowdown of the economy in 2016.”
The average salary of St Gallen’s alumni jumped to $102,000 three years after graduation compared with $90,000 last year.
Mila Kunis just keeps on raking in those sexy titles.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The Internet has flattened the world, and Facebook has banded us together as one big family. Our grandfathers inherited regions, my generation inherited nations, you have inherited the world. You are now only 4.74 people away from any human being and an average of two days away from any inhabited corner of the world. So travel. Africa, Europe, India, China or Brazil, go where you can learn the most, embrace what can teach you the most.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
金球奖的独特之处在于其同时设置电影和电视奖项。而当地时间周日的这场典礼更是前所未有地模糊了二者的界限，大大褒奖了电视领域这一年来的出众表现。现已剧终的热门电视剧集《绝命毒师》(Breaking Bad)今年首次拿下金球奖，赢得了当晚最热烈的欢呼声。该片荣获剧情类最佳系列剧集奖，片中演员布赖恩?克兰斯顿(Bryan Cranston)荣获剧情类系列剧最佳男演员。
Inhibition of SARS coronavirus helicase by bismuth complexes
ESCP欧洲商学院(ESCP Europe)和美国麻省理工学院斯隆管理学院(MIT Sloan School of Management)也表现不错。两所学院的排名均上升5位，分别位居第三和第五。
其他列入前十的热门搜索项中除了一个以外，都反映了公众对名人的痴迷。青少年热捧的流行小天后麦莉 赛勒斯在热门搜索项中排行第三，紧跟其后排在第四位的是电视明星金 卡戴珊。嘎嘎小姐排在第五位，女演员梅根 福克斯排在第七，前十名的其他几位分别是贾斯汀 比伯、美国偶像和小甜甜布兰妮。排在第六位的iPhone是个例外。
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
管理着4亿美元资产的基金公司AIS Group的首席投资长赫梅尔(John Hummel)称，全球所有新原油资源的开采成本都较高。他预计到2015年美国页岩油产量将下降。
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
In an effort to protect China's role in the global economy as a manufacturing hub, the central bank devalued the currency in August, in the biggest drop in decades. Later in the year, after the International Monetary Fund added the renminbi to its group of global reserve currencies, the value of the currency fell further, possibly reflecting capital outflows.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
People on both sides of the Taiwan Strait are brothers and sisters, and no matter how the situation on the island evolves, the mainland is determined to maintain Cross-Strait stability.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
The Mensa Supervised IQ Test can only be taken by children aged over ten-and-a-half and consists of two separate industry-standard assessments. One measures mainly verbal reasoning skills and the other, which includes diagrams and images, assesses visual and spatial logic. And Nishi, from Audenshaw in Tameside, scored the highest possible mark of 162 in the first test – known as the Cattell III B score. She scored 142 in the second element, the Culture Fare Scale, with the results putting her in the top one per cent of the nation in terms of IQ. Anyone scoring a percentile of two in any Mensa test is admitted to the society.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
May its blessings lead into a wonderful year for you and all whom you hold dear.祝福你及你所爱的人新的一年中万事如意。
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
The consumer price index rose by 1.8 per cent year-on-year in January, from 1.6 per cent in December 2015. However, CPI continues to trail Beijing’s target of “around 3 per cent“.
圣文森特(St. Vincent)，《数码证人》(Digital Witness)， Loma Vista/Republic
Mr Cook must balance that with the secrecy that surrounds its product development. Already, there are whispers on Apple’s campus about another secret project, on the scale of the iPhone or Watch, which is pulling in talent from across Cupertino.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Bingo! In fewer than 20 words it combined five previous years’ winners, only to say nothing at all. With a heavy heart, I award eBay my overall Golden Flannel Award for 2016.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
An Australian woman whose cats ate each other after she abandoned them in her home has been convicted of animal cruelty.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Outbound investment for the period totalled $86.3bn, according to the Ministry of Commerce.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
China and its southern neighbour failed to come to an agreement on cross-border trade last month during Vietnamese president Truong Tan Sang's state visit to China, where he met with his counterpart Xi Jiping.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
The 30 percent increase is to be driven bymore specialty drug innovation, greater patient access to medicines and reducedimpact from patent expiry dates.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
But the duo topped the trending celebrities section followed by 'X Factor' judges Gary Barlow and Tulisa.
10. “Results” (Andrew Bujalski)
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
For generations, working-class whites were doubly blessed: they enjoyed privileged status based on race, as well as the fruits of broad economic growth.
While you're studying, pay attention to the material you know will be on a test and write a quick practice question. Start a new document on your laptop and add questions as you think of them.
These artificial ears will be a huge benefit to those who suffer injuries or who have microtia, a condition that keeps the ears from ever developing.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
In the open ranking, IMD, in Lausanne, scores particularly highly in the top 10 criteria based on a survey of executives who attended programmes. It is ranked first in three criteria and in the top five for the remaining seven.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
No.1: Einstein Alive Again?
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
而传统主义者诸如乔治·克鲁尼（George Clooney），他因影片《逃离德黑兰》（Argo）获最佳影片奖以及在影片《辛瑞那》（Syriana ）中获最佳男配角，他的奥斯卡奖杯放在家中的书房。达斯汀·霍夫曼（Dustin Hoffman）曾在1980年因影片《克莱默夫妇》（Kramer vs. Kramer） 、并在九年后因影片《雨人》（Rain Man）两次获最佳男主角奖，也将其奖杯放在书房中。
'What I was trying to do was wrap myself in his mantle and write a book that would be worthy of him.'
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Major areas of work for 2017
"The longer people sit out of the job market, the harder it's going to be for them to re-enter," Frederickson says.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
Drivers of China's online ride-hailing services will be required to hold a license by passing exams in November.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
乔布斯在苹果大会上作专题演讲后展示MacBook Air ，2008年，1月15日，旧金山
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Do you routinely roll your eyes? Do you have a weak handshake? Do you avoid making eye contact? These could all be career killers. People must understand that actions speak louder than words. And the majority of our communication is done through non-verbal cues. People could perceive some of your non-verbal communication habits as rude or unprofessional—and these things could eventually have a significant impact on the advancement of your career.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
One fifth of the rich in the 500 list are from the information technology industry, and capital players are fading away from the list.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
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Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
50个最优秀的“无工作经验要求”项目的所有毕业生中，三分之一以上毕业于英国的商学院。英国的商学院还吸引了近一半的女学生以及近一半的国际学生。实际上，2014年一个英国“无工作经验要求”金融硕士项目招收的学生中，有94%来自海外。这些学生当中约有85%来自欧洲经济区(European Economic Area)以外，55%来自中国内地。
Despite the overall upward trends in financing, the amount of capital raised by women-owned businesses has historically lagged when compared to men. For example, in the first half of 2013, women made up only 16 percent of businesses seeking funding, with only 24 percent of the women receiving angel funding, Plum Alley, an online e-commerce platform for female entrepreneurs, recently launched a crowdfunding platform specifically focused on helping women innovators get to the next level. And as the first platform of its kind in the exploding crowdfunding space (expected to hit $3.98 billion next year), we can certainly expect Plum Alley to play a big role in the entrepreneurial landscape for women in the year to come.
Length-scale dependence of protein hydration-shell density
The company is hardly alone in its efforts to woo talent of a different sort. Earlier this year Intel announced a collaboration with the Council of Fashion Designers of America, or CFDA, kicking off a partnership with the high-concept retailer Opening Ceremony to design its smart bracelet. Tory Burch partnered with Fitbit to design pendants and bracelets akin to the Shine Tracker by Misfit Wearables. And Apple AAPL -1.03% has tapped a diverse group of people, including former Burberry chief executive Angela Ahrendts (to lead its retail efforts), former Yves Saint Laurent CEO Paul Deneve, and former Nike NKE -0.71% design director Ben Shaffer.
2. Tell all your friends not to give birth or wed or die or whatever during the World Cup coz we won’t go.
The remains of the monarch -- depicted by William Shakespeare as a monstrous hunchback and often viewed as one of English history's greatest villains -- will now be solemnly reburied in the local cathedral.
The school is also second for its international course experience. More than four in five of its latest graduating cohort went on an internship abroad and over half studied in another country for more than a month.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
"We have called the police and collected evidence to protect the company's reputation. Those who leaked the nude pictures will be punished according to law," the announcement read.
Neumann, Silbermann and Sharp are three of 66 billionaires under 40 years old, a record for the Forbes list.
Bigcommerce does particularly well among small retailers generating $1 million to $2 million in annual revenue, although its following with those in the $20 million to $30 million range is growing quickly. Roughly 70% of its existing customer base also runs a bricks-and-mortar store. For the past year, the developer has worked hard on responsive storefront templates that work equally well on mobile platforms and desktops—design is the number-one consideration for small e-commerce merchants, it says—and on relationships with partners of “adjacent” cloud services from the accounting, payments, customer relationship management, and payroll management worlds.
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